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  3. Peripheral contributions to resting state brain dynamics
Department of Brain and Cognitive Sciences (BCS)
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Peripheral contributions to resting state brain dynamics

Speaker(s)
Sarah Bricault (Jasanoff Lab)
Add to CalendarAmerica/New_YorkPeripheral contributions to resting state brain dynamics03/30/2021 4:00 pm03/30/2021 5:00 pmZoom Webinar
March 30, 2021
4:00 pm - 5:00 pm
Location
Zoom Webinar
Contact
Jon Gauthier
    Description

    Zoom meeting URL: https://mit.zoom.us/j/94106216215

    The correlational structure of brain-wide activity dynamics in the absence of stimuli or behavior is often assumed to reveal intrinsic properties of neural function. To probe the validity of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in the rat somatosensory system. We find that perturbation of sensory input pathways alters correlation strengths found throughout the system under a range of behavioral conditions, despite the absence of ostensible stimuli or movements. Differences in peripheral input also help explain a functional connectivity phenotype observed in a rat model of syndromic autism spectrum disorder, emphasizing the relevance of brain-periphery interactions to neurological diagnoses. These results indicate that resting state brain activity arises from a matrix of intrinsic and extrinsic influences.

    Speaker Bio

    Sarah Bricault is a postdoc in the Jasanoff Lab. Her research interests include using functional MRI to investigate resting state functional connectivity and motivated behavior in vivo.

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