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https://mit.zoom.us/j/98134025477 

The human brain has expanded cellular diversity, unique patterns of neuronal connectivity, and protracted developmental stages relative to those of other mammals. Undoubtedly, novel molecular mechanisms evolved to orchestrate these differences and are critical to brain function. Neuronal activity–dependent gene expression shapes the morphology, excitability, and connectivity of neurons in a cell type–specific fashion. Although this process is often dysregulated in human brain disorders, the transcriptional and epigenetic effects of neuronal activity have only been systematically explored in rodents. We take genomic and molecular approaches to uncover novel human neuronal activity–dependent gene expression and previously unappreciated patterns of neurological disease heritability. Using human and primate model systems, we have explored the evolution of the osteocrin (OSTN) gene, which is repurposed in the primate brain. Functional experiments in human neurons and primate will provide fundamental insights into the uniquely-primate molecular mechanisms of human brain development and function.