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  3. SCSB Lunch Series: Role of FMRP interactions with presynaptic ion channels in Fragile X Syndrome
SCSB Lunch Series: Role of FMRP interactions with presynaptic ion channels in Fragile X Syndrome
Simons Center for the Social Brain

SCSB Lunch Series: Role of FMRP interactions with presynaptic ion channels in Fragile X Syndrome

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Add to CalendarAmerica/New_YorkSCSB Lunch Series: Role of FMRP interactions with presynaptic ion channels in Fragile X Syndrome05/10/2024 12:00 pm05/10/2024 1:00 pmSimons Center Conference room, 46-6011,46-6011
May 10, 2024
12:00 pm - 1:00 pm
Location
Simons Center Conference room, 46-6011,46-6011
Contact
ASOKHINA@MIT.EDU
    Description

    Date: Friday, May 10,  2024
    Time: 12:00pm – 1:00pm
    Location: Simons Center Conference room 46-6011 + Zoom Meeting: https://mit.zoom.us/j/91647033337

    Speaker: Chhavi Sood, Ph.D.
    Affiliation: Simons Postdoctoral Fellow, Littleton Lab, Picower Institute, BCS, Department of Biology, MIT

    Talk title: Role of FMRP interactions with presynaptic ion channels in Fragile X Syndrome

    Abstract: Synaptic vesicle (SV) fusion occurs in response to Ca2+ influx from voltage-gated Ca2+ channels (VGCCs) at AZs. Multiple conserved proteins cluster SVs and VGCCs at the AZs. Additionally, BK channels (Ca2+-activated K+ channels) also cluster at AZs to rapidly repolarize the presynaptic membrane, close VGCCs, and terminate Ca2+ influx and SV release. Using the Drosophila model of Fragile X Syndrome (FXS) and neuromuscular junction, I aim to determine how FMRP controls VGCC and BK channel synaptic delivery and AZ abundance and how dysregulation of these interactions contributes to synaptic defects in FXS.

     

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