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  3. SCSB Lunch Series: Probing the cortical circuits that prevent sensory overload
SCSB Lunch Series: Probing the cortical circuits that prevent sensory overload
Simons Center for the Social Brain

SCSB Lunch Series: Probing the cortical circuits that prevent sensory overload

Add to CalendarAmerica/New_YorkSCSB Lunch Series: Probing the cortical circuits that prevent sensory overload02/11/2022 12:00 pm02/11/2022 1:00 pm,
February 11, 2022
12:00 pm - 1:00 pm
Location
,
Contact
asokhina@mit.edu
    Description

    Date: Friday, February 11, 2022
    Time: 12:00pm – 1:00pm
    Location: Zoom meeting – https://mit.zoom.us/j/95876605075

    Speaker: Alex Major, Ph.D.
    Affiliation: Simons Postdoctoral Fellow, Earl Miller Laboratory, Picower Institute for Learning and Memory, MIT

    Host: Dr. Earl Miller

    Talk title: Probing the cortical circuits that prevent sensory overload

    Abstract: Sensory overload in autism spectrum disorder (ASD) may result from disrupted filtering of predicted sensory inputs. Our Predictive Coding model of brain function suggests sensory information is carried by gamma rhythms in the upper layers of the cortex. In contrast, alpha/beta rhythms are in deep layers and may suppress gamma rhythms of predicted sensory input. We hypothesize feedback prediction signals in ASD are deficient, manifesting as reduced alpha/beta rhythms. This causes less suppression of incoming sensory input and gamma, leading to sensory overload. We have developed a technique to simulate sensory overload in rhesus monkeys by suppressing deep layers of prefrontal cortex. This is hypothesized to decrease feedback alpha/beta activity and thus disinhibit gamma activity and sensory input. This will directly test a mechanism of sensory overload, perhaps leading research towards improved symptom management.

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