Mapping computations to circuits: Neural coding transformation in the thalamocortical circuit during active sensation
Description
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One fundamental question in neuroscience remains largely unanswered: how are computations implemented by structured neural circuits? Over the last fifty years we have learned how sensory, motor and cognitive information is represented in different regions of the mammalian brain. Anatomical studies are beginning to reveal precisely structured neural circuits, including stereotyped circuit motifs across brain areas subserving different functions. However, linking physiology and detailed anatomy remains elusive in most cases. We know little about activity in specific cell types, the nodes of the circuit diagram, in behaving animals.
We study how tactile information is represented in different brain circuits in the mice vibrissal system. We train mice to move their whiskers to judge the location of an object presented in one of several locations and record extra- and intracellularly from specific neural types in this circuit. I’ll present recent results showing how tactile information is processed and transformed by specific neural types and circuits as it ascends from the sensory periphery to cortex.