Food Mind Control: Regulation of Sensory Behaviors by Bacterial Diet in C. Elegans.
Description
Professor of Biology, Neurogenetics of behavior and development.
We are interested in identifying the genetic, molecular, and neuronal mechanisms by which animals sense and translate environmental cues such as chemicals and temperature into specific changes in behavior and development. Understanding the regulation of sensory signaling and signal processing is of significant biomedical importance since misregulation of these pathways leads to many neurological and behavioral disorders.
Current research in our lab focuses on three main areas using the powerful and elegant C. elegans model organism. We use a multifaceted strategy combining genetic, genomic, and molecular tools, high resolution analyses of ultrastructure and in vivo protein trafficking, quantitative behavioral assays, and in vivo calcium imaging to explore the following issues.
- We are investigating the molecular and cellular mechanisms that define the unique morphological and functional properties of sensory cilia, cellular antennae that house all signaling molecules, and represent the site of primary sensory signal transduction.
- We are identifying the genes and neurons required for the response of C. elegans to pheromones, small molecules used in chemical communication within a species.
- We are studying the molecular, neuronal and circuit mechanisms required for the remarkable experience-dependent responses of C. elegans to thermal stimuli.
Speaker Bio
Department of Biology
Brandeis University
Waltham, MA 02454
781-736-2686
Education and Research experience
1985-91 Doctoral research with Dr. Brent Cochran, MIT, MA
1991-96 Postdoctoral research with Dr. Cori Bargmann, UCSF, CA
1996 – 2002 Assistant Professor of Biology, Brandeis University, MA
2002 – 2007 Associate Professor of Biology, Brandeis University, MA
2007 – present Professor of Biology, Brandeis University, MA
2002 – 2011 Chair, Molecular and Cell Biology Graduate Program, Brandeis University, MA
2017 – 2020 Chair, Department of Biology, Brandeis University, MA
Professional activities
Professional activities
2002 - 2012 Editorial Board, Genes Brain and Behavior
2007 - 2010 Editorial Board, Developmental Neurobiology (formerly J. Neurobiology)
Editorial Board, BMC Neuroscience
2010 – 2014 Section Editor, Sensory Systems, BMC Neuroscience
2011 – 2017 Associate Editor, Genetics
2012 – 2014 Editorial Board, PLoS Biology
2014 – 2017 Reviewing Editor, eNeuro
2014 - present Advisory Board, PLoS Biology
2015 – present Section Editor, Neurobiology and Behavior, WormBook (in Genetics)
2016 – present Editorial Board, Current Opinion in Neurobiology
2017 – 2020 Board of Reviewing Editors, eLife
2020 (upcoming) Senior Editor, eLife
1998 – present ad hoc reviewer for NSF, NIH, HFSP, HHMI predoctoral fellowships, MRC (UK),
ZonMW (Netherlands), ANR (France), Health Research Board (Ireland), US-Israel
BiNational Foundation, Wellcome-India Trust, multiple NIH study sections
2005 - 2009 Member, Scientific Review Board, The Medical Foundation, MA
2005 - 2009 Standing member, NDPR study section, NIH
2014 – 2017 Member/co-chair, Fellowship Review Committee, HFSP
2017 Member, External Review Committee, Columbia University Neuroscience Graduate
Program
2014 - 2020 Standing member, NCF study section, NIH
2016 – 2020 Advisory Board, Searle Scholars Foundation
1996 Co-organizer, Boston Area Neuroscience Group
1998 Co-organizer, East Coast C. elegans meeting
2005, 2007, 2015 Organizing committee, International C. elegans meeting
2008, 2010 Elected co-chair and chair, Neural Development Gordon Conference
2015 – 2018 Program Committee, Society for Neuroscience Annual Meeting
2019 Organizer, Cilia and the Brain, Les Treilles Foundation Conference
2020 Organizing committee, The Allied Genetics Conference 2020
2021 Co-organizer, International C. elegans Conference
2022 Co-organizer, Keystone meeting on Cilia, Development and Disease
Membership in Professional Organizations
American Association for the Advancement of Science
Society for Neuroscience
Genetics Society of America
American Society for Cell Biology
Honors
1996-98 Alfred P. Sloan Research Fellow
1996-99 Searle Scholar
1997-99 Harcourt General New Investigator
1997-02 Packard Foundation Fellow
2002 Alberta Gotthard and Henry Strage Award
2010 NIGMS MERIT award
2017 – 2019 Elected Treasurer, Genetics Society of America
2019 Elected Fellow, American Association for the Advancement of Science (AAAS)
Publications
Hayes, T.E., Sengupta, P. and Cochran, B.H. (1988). The human c-fos serum response factor and the yeast factors GRM/PRTF have related DNA-binding specificities. Genes Dev. 2:1713-22.
Sengupta, P. and Cochran, B.H. (1990). The PRE and PQ box are functionally distinct yeast pheromone response elements. Mol Cell Biol. 10:6809-12.
Sengupta, P. and Cochran, B.H. (1991). MAT1 can mediate gene activation by a-mating factor. Genes Dev. 10:1924-34.
Sengupta, P., Colbert, H.A., Kimmel, B.E., Dwyer, N. and Bargmann, C.I. (1993) The cellular and genetic basis of olfactory responses in C. elegans. Ciba Found Symp. No. 179. The Molecular Basis of Smell and Taste Transduction, 22:235-50.
Sengupta, P., Colbert, H. and Bargmann, C.I. (1994) The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily. Cell 79:971-80.
Sengupta, P., Chou, J.H. and Bargmann, C.I. (1996) odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell 84:899-909.
Chou, J.H., Troemel, E.R., Sengupta, P., Colbert, H.A. et al. (1996) Olfactory recognition and discrimination in C. elegans. Cold Spring Harbor Symp Quant Biol. 61:157-64.
Sengupta, P. and Bargmann, C.I. (1996) Cell fate specification and differentiation in the nervous system of C. elegans. Dev Genet 18:73-80.
Sengupta, P., (1997) Cellular and molecular analyses of olfactory behavior in C. elegans. Sem Cell Dev Biol. 8:153-62.
Dwyer, N.D., Troemel, E.R., Sengupta, P., and Bargmann, C.I. (1998) Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell 93:455-66.
Miyabayashi, T., Palfreyman, M.T., Sluder, A.E., Slack, F. and Sengupta, P. (1999) Expression and function of members of a divergent nuclear receptor family in C. elegans. Dev Biol. 215:314-31.
Sengupta, P. and Carlson, J. (2000) Genetic models in chemoreception in Neurobiology of Taste and Smell. (T.E. Finger, W.L. Silver and D. Restrepo, eds.) pp 41-72. Wiley Press, New York, USA.
Chou, J.H., Bargmann, C.I. and Sengupta, P. (2000) The C. elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction. Genetics 157:211-24.
Daniels, S.A., Ailion, M., Thomas, J.H. and Sengupta, P. (2000) egl-4 acts through a TGF-/SMAD pathway in C. elegans to regulate multiple neuronal circuits in response to sensory cues. Genetics 156:123-41.
Sarafi-Reinach, T.R. and Sengupta, P. (2000) The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans. Genes Dev. 14:2472-85.
Sarafi-Reinach, T.R., Melkman, T., Hobert, O. and Sengupta, P. (2001) The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans. Development 128:3269-81.
Satterlee, J.S., Sasakura, H., Kuhara, A., Berkeley, M., Mori, I. and Sengupta, P. (2001) Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of orthodenticle/Otx. Neuron 31:943-56.
Lanjuin, A., and Sengupta, P. (2002) The KIN-29 Ser/Thr kinase regulates chemosensory receptor expression and neuroendocrine signaling in C. elegans. Neuron, 33:369-81.
Fujiwara, M., Sengupta,P., and McIntire, S. (2002) Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 36:1091-1102.
Nolan, K.M., Sarafi-Reinach, T.R., Horne, J.G., Saffer, A.M. and Sengupta, P. (2002) The DAF-7 TGF- signaling pathway regulates chemosensory receptor gene expression in C. elegans. Genes Dev. 16:3061-73.
Sengupta, P. (2002) Chemosensation: Tasting with the tail. Curr Biol. 12:R386-88.
Colosimo, M.E., Tran, S. and Sengupta, P. (2003) The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in C. elegans. Genetics 165:1779-91.
Lanjuin, A., VanHoven, M.K., Bargmann, C.I., Thompson, J.K. and Sengupta, P. (2003) Otx/otd homeobox genes specify distinct neuron identities in C. elegans. Dev Cell. 5:621-33.
Satterlee, J.S., Ryu, W.S. and Sengupta, P. (2004) The CMK-1 Ca2+/calmodulin-dependent protein kinase I and the TAX-4 cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr Biol. 14:62-8.
Melkman, T. and Sengupta, P. (2004) The worm’s sense of smell: Development of functional diversity in the chemosensory system of C. elegans. Dev Biol. 265:302-19.
Lanjuin, A. and Sengupta, P. (2004) Specification of chemosensory neuron subtype identities in C. elegans. Curr Op Neurobiol. 14:22-30.
Sengupta, P. (2004) Taking sides in the nervous system with miRNA. Nat Neurosci. 7:100-2.
Colosimo, M.E., Brown, A., Mukhopadhyay, S., Gabel, C., Lanjuin, A., Samuel, A.D.T. and Sengupta, P. (2004) Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Curr Biol. 14:2245-51.
Melkman, T. and Sengupta, P. (2005) Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1. Development 132:1935-1949.
Samuel, A.D.T. and Sengupta, P. (2005) Sensorimotor integration: Locating locomotion in worm neural circuits. Curr Biol. 15:R341-3.
Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K. and Mori, I. (2006) Identification of guanylyl cyclases that function in thermosensory neurons of C. elegans. Genetics. 172:2239-52.
Kim, Kyuhyung, Colosimo, M.E., Yeung, H. and Sengupta, P. (2005). The UNC-3 Olf/EBF protein represses alternate neuronal programs to specify chemosensory neuron identity. Dev Biol. 286:136-148.
Lanjuin, A., Claggett, J., Shibuya, M., Hunter, C.P. and Sengupta, P. (2006). Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1. Dev Biol. 290:139-51.
Clark, D. A. Biron, D., Sengupta, P. and Samuel, A.D.T. (2006) The AFD sensory neurons encode multiple functions underlying thermotactic behavior in C. elegans. J Neurosci. 26:7444-51.
Biron, D., Shibuya, M., Gabel, C., Brown, A., Clark, D.A., Wasserman, S.M., Sengupta, P.*, and Samuel A.D.T.* (2006) Regulation of thermotactic behavioral plasticity by a diacylglycerol kinase in C. elegans. Nat Neurosci. 9: 1499-505.
van der Linden, A.M., Nolan, K.M. and Sengupta, P. (2007; epub 2006) KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a Class II HDAC. EMBO J. 26:358-70.
Sengupta, P. (2007) Generation and modulation of chemosensory behaviors in C. elegans. Pflug Archiv Eur J Phys. 454:721-34.
Mukhopadhyay, S., Liu, Y, Qin, H., Lanjuin. A., Shaham, S. and Sengupta, P. (2007). Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. EMBO J. 26:2966-80.
Chi, C.A., Clark, D.A., Lee. S., Biron, D., Gabel, C.V., Brown, J., Sengupta, P. and Samuel, A.D.T. (2007) Long-term plasticity in C. elegans thermotactic behavior does not require association between temperature and food-dependent cues. J Exp Biol. 210:4043-52.
Sengupta, P. and Thomas, J.H. (2007) From eye of newt to chemical structure. Nat Chem Biol. 3:368-9.
Huang, S.L.B., Saheki, Y., VanHoven, M.K., Toroyama, I., Ishihara, T., Katsura, I., van der Linden, A., Sengupta, P. and Bargmann, C.I. (2007) Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Dev. 6:24.
Sengupta, P. (2007) The worm turns. Nature, 450:35-6.
Omori, Y., Zhao, C., Saras, A., Mukhopadhyay, S., Kim. W., Furukawa, T., Sengupta, P., Veraksa, A., and Malicki, J. (2007). Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase, Rab8. Nat Cell Biol. 10:437-44.
Mukhopadhyay, S., Liu, Y, Qin, H., Lanjuin. A., Shaham, S. and Sengupta, P. (2008). Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans. Dev Cell. 14: 762-74.
Biron, D., Wasserman, S., Thomas, J.H.T, Samuel, A.D.T. and Sengupta, P. (2008) An olfactory neuron responds stochastically to temperature and modulates C. elegans thermotactic behaviors. PNAS 105:11002-11007.
van der Linden, A.M., Wiener, S., You, Y-J., Kim, K., Avery, L. and Sengupta, P. (2008) The EGL-4 PKG acts with the KIN-29 SIK and KIN-2 PKA to regulate chemoreceptor gene expression and sensory behaviors in C. elegans. Genetics 180:1475-1491.
Kim, K., Sato, K., Shibuya, M., Zeiger, D.M., Butcher, R.A., Ragains, J.R., Clardy, J., Touhara, K. and Sengupta, P. (2009) Two chemoreceptors mediate the developmental effects of dauer pheromone in C. elegans. Science 326:994-998.
Nokes, E.B., van der Linden, A.M., Winslow, C., Mukhopadhyay, S., Ma, K. and Sengupta, P. (2009) Cis-regulatory mechanisms of gene expression in an olfactory neuron type in C. elegans. Dev Dyn. 238:3080-3092.
Sengupta, P. and Samuel, A.D. (2009) C. elegans: a model system for systems neuroscience. Curr Opin Neurobiol. 19:637-643.
Hall, S. E., Beverly, M.B., Russ, C., Nusbaum, C. and Sengupta, P. (2010) A cellular memory of developmental history generates phenotypic diversity in C. elegans. Curr Biol. 20:149-155.
Kim, K., Kim, R. and Sengupta, P. (2010) The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans. Development, 137: 963-974.
van der Linden, A.M., Beverly, M., Kadener, S., Rodriguez, J., Wasserman, S., Rosbash, M. and Sengupta, P. (2010) Genome-wide analyses of light and temperature-entrained circadian transcripts in C. elegans. PLoS Biol 8: e1000503.
Garrity, P.A., Goodman, M.B., Samuel, A.D., Sengupta, P. (2010) Running hot and cold: behavioral strategies, neural circuits and the molecular machinery for thermotaxis in C. elegans and Drosophila. Genes Dev. 24: 2365-2382.
Wasserman, S.M., Beverly, M. Bell, H. and Sengupta, P. (2011) Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling. Curr Biol. 21: 353-362.
Sengupta, P. and Schedl, T. (2011) Cellular reprogramming: chromatin puts on the brake. Curr Biol. 21:R157-159.
Beverly, M., Anbil. S. and Sengupta, P. (2011) Degeneracy and signaling within a sensory circuit contributes to robustness in thermosensory behaviors in C. elegans. J Neurosci. 10: 11718-11727.
Wright, K.J., Baye, L.M., Olivier-Mason, A., Mukhopadhyay, S., Sang, L., Kwong, M., Wang, W., Pretorius, P.R., Sheffield, V.C., Sengupta, P., Slusarski, D.C., and Jackson, P.K. (2011) An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev 25: 2347-2360.
Kaplan, O.I., Doroquez, D.B., Cevik, S., Bowie, R.V., Clarke, L., Sanders, A.A., Kida, K., Rappoport, J.Z., Sengupta. P.* and Blacque, O.E.*. (2012) Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia. Curr Biol. 22: 451-460.
Jang, H., Kim, K., Neal, S.J., Macosko, E., Kim, D., Butcher, R.A., Zeiger, D.M., Bargmann, C.I*. and Sengupta, P*. (2012) Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans. Neuron 75:585-92.
Sengupta, P. (2013; epub 2012) The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses. Curr Opin Neurobiol. 23: 68-75.
Hall, S.E, Chirn, G-W., Lau, N.C. and Sengupta, P. (2013) RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans RNA, 19:306-319.
Olivier-Mason, A., Wojtyniak, M., Bowie, R.V., Blacque, O.E., and Sengupta, P. (2013) Transmembrane protein OSTA-1 shapes cell type-specific sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans. Development 140: 1560-1572.
Sengupta, P. and Garrity. P. (2013) Sensing temperature. Curr Biol. 23: R304-307.
Neal, S.J., Kim, K. and Sengupta, P. (2013) Quantitative assessment of pheromone-induced dauer formation in C. elegans. Methods Mol Biol. 1068:273-283.
Goodman, M., Klein. M., Lasse, S., Luo, L., Mori, I., Samuel, A.D., Sengupta, P. Wang, D. (alphabetical) (2013) Thermotaxis navigation behavior. Wormbook doi: 10.1895/wormbook.1.168.1.
Wojtnyiak, M., O’Halloran, D. and Sengupta, P. (2013) Cell- and subunit-specific mechanisms of CNG channel ciliary targeting and localization in C. elegans. J Cell Sci. 126: 4381-4395.
Nechipurenko, I.V., Doroquez, D.B. and Sengupta, P. (2013) Primary cilia and dendritic spines: different but similar signaling compartments. Mol Cells. 4: 288-303.
Doroquez, D.B., Berciu, C., Anderson, J.R., Sengupta, P*. and Nicastro, D*. (2014) A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in C. elegans. eLife 2014;3:e01948.
Sengupta, P., Wang, J., Barr, M.M. (2014) New insights into an old organelle: Meeting report on Biology of Cilia and Flagella. Traffic. Traffic, 15: 717-726.
Brear, A.G., Yoon, J., Wojtnyiak, M. and Sengupta, P. (2014) Diverse cell-specific mechanisms localize G protein-coupled receptors to C. elegans sensory cilia. Genetics 197: 667-684.
Ryan, D.A., Miller, R.M., Lee. K., Neal. S.J., Fagan, K.A., Sengupta, P. and Portman, D. (2014). Sex, age and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor regulation. Curr Biol. 24: 2509-2517.
Yu, Y.V., Bell. H.W., Glauser, D., Van Hooser, S.D., Goodman, M.B. and Sengupta, P. (2014) CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron Neuron 84: 919-926.
Schild, L.C., Wang, D., Bell, H.B., Yu, Y.V., Agin, R., Sengupta, P., Goodman, M.B. and Glauser, D.A. (2014) The balance between cytoplasmic and nuclear CaM Kinase-1 signaling controls the operating range for noxious heat avoidance. Neuron 84: 983-996.
Neal, S.J., Takeishi, A., O’Donnell, M.P., Park, J., Hong, M., Butcher, R.A., Kim. K. and Sengupta P. (2015) Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. eLife 4: e10110.
Takeishi, A., Yu, Y.V., Hapiak, V.M., Bell, H.W., O’Leary, T. and Sengupta P. (2016) Receptor-type guanylyl cyclases confer thermosensory responses in C. elegans. (*- co-first authors). Neuron 90: 235-244.
Neal, S.J., Park, J., Yoon, J., Shibuya, M., Schroeder, F.C., Butcher, R.A., Kim, K. and Sengupta, P. (2016) A forward genetic screen for molecules involved in pheromone-induced dauer formation in C. elegans. G3. 6: 1475-1487.
Sims, J.R., Ow, M.C., Nishiguchi, M., Kim, K., Sengupta, P. and Hall, S.E. (2016) Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways. eLife e11642.
Nechipurenko, I.V., Olivier-Mason, A., Kennedy, J., McLachlan, I.G., Heiman, M.G., Blacque, O.E. and Sengupta, P. (2016) A conserved role for Girdin in basal body positioning and ciliogenesis. Dev Cell 38: 493-506.
Cornils, A., Maurya, A.K., Chung, S.H., Kennedy, J., Brear, A. G., Gabel, C.V., Blacque, O.E. and Sengupta, P. (2016) Structural and functional recovery of sensory cilia in C. elegans IFT mutants upon aging. PLoS Genet 12: 1006325.
Nechipurenko, I.V., Berciu, C., Sengupta, P*. and Nicastro, D*. (2017) Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans. eLife e25686.
Sengupta, P. (2017) Cilia and Sensory Signaling: The journey from ‘animalcules’ to human disease. PLoS Bio. e2002240.
Nechipurenko, I.V. and Sengupta, P. (2017) The rise and fall of basal bodies in the nematode Caenorhabditis elegans. Cilia. 6:9.
Hong, M., Ryu, L., Ow, M.C., Kim, J., Je, A.R., Huh, Y.H., Lee, K.J., Butcher, R.A., Choi, H., Sengupta, P., Hall. S.E. and Kim, K. (2017) Early pheromone experience modifies a synaptic activity to influence adult pheromone responses of C. elegans. Curr Biol. 27: 3168-3177.
Kazatskaya, A., Kuhns, S., Lambacher, N.J., Kennedy, J.E., Brear, A.G., McManus, G.J., Sengupta, P*. and Blacque, O.E*. (2017) The atypical MAP kinase MAPK15 regulates primary cilium formation and protein trafficking in C. elegans and human cells. Genetics. 207: 1423-1440.
Goodman, M.B. and Sengupta, P. (2018) The extraordinary AFD thermosensor of C. elegans. Pflug Archiv Eur J Physiol. 470: 839-849.
O’Donnell, M.P., Chao, P-H., Kammenga, J.E. and Sengupta, P. (2018) Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLoS Genet. 14: e1007213.
O’Donnell, M.P., Khan, M., Sengupta, P. (2018) Thermosensation: Human parasitic nematodes use heat to hunt hosts. Curr Biol. 28: R795-798.
Maurya, A.K., Rogers, T. and Sengupta, P. (2019) A CCRK and MAK kinase modulate cilia branching and length via regulation of axonemal microtubule dynamics. Curr Biol, 22: 1286-1300.
Goodman, M.B. and Sengupta, P. (2019) How C. elegans senses mechanical stress, temperature, and other physical stimuli. Genetics. 212: 25-51.
Woldemariam, S., Nagpal. J., Hill, T. Li, J., Schneider, M., Shankar, R., Futey, M., Varshney, A., Ali, N., Mitchell, J., Andersen, K., Barsi-Rhyne, B., Tran, A., Steuer Costa, W., Krzyzanowski, M.C., Yu, Y.V., Brueggemann, C., Hamilton, S., Ferkey, D., VanHoven, M., Sengupta, P., Gottschalk, A., and L’Etoile, N. (2019) Robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans. Genetics 213: 59-77. PMCID: PMC6482063
DiTirro, D., Philbrook, A., Rubino, K. and Sengupta, P. (2019) The C. elegans Tubby homolog dynamically modulates olfactory cilia morphogenesis and phospholipid composition. eLife, e48789.
O’Donnell, M.P., Fox. B.W., Chao, P-H., Schroeder, F.C., and Sengupta, P. (2019) Modulation of sensory behavior and food choice by an enteric bacteria-produced neurotransmitter. BioRxiv, doi: https://doi.org/10.1101/735845, In revision.
Current Research Support
1. R21 NS101702 (PI: Sengupta) 1/15/17 - 1/15/20
NIH/NINDS (Sengupta); Modulation of chemosensory behaviors by gut microbiota
2. R35 GM122463 (PI: Sengupta) 5/1/17 - 4/30/22
NIH/NIGMS: Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticity
3. IOS 1655118 (PI: Sengupta) 6/1/17 - 5/31/21
NSF/IOS: Mechanisms of chemosensory behavioral plasticity in C. elegans
4. R21 MH118464 (PIs: Sengupta, Turrigiano) 7/1/19 – 6/30/21