Education

PhD 1993, Harvard University

Research Summary

We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.

Awards

• National Academy of Sciences, Member, 2011
• Howard Hughes Medical Institute, HHMI Investigator, 2005
• National Academy of Sciences Award in Molecular Biology, 2005
• AAAS Newcomb Cleveland Prize, 2002

Key Publications

1. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
   doi: 10.1016/j.cell.2018.05.022PMID:29887379
2. Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Wu, X, Bartel, DP. 2017. Cell 169, 905-917.e11.
   doi: 10.1016/j.cell.2017.04.036PMID:28525757
3. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Guo, JU, Bartel, DP. 2016. Science 353, .
   doi: 10.1126/science.aaf5371PMID:27708011
4. Predicting effective microRNA target sites in mammalian mRNAs. Agarwal, V, Bell, GW, Nam, JW, Bartel, DP. 2015. Elife 4, .
   doi: 10.7554/eLife.05005PMID:26267216
5. Poly(A)-tail profiling reveals an embryonic switch in translational control. Subtelny, AO, Eichhorn, SW, Chen, GR, Sive, H, Bartel, DP. 2014. Nature 508, 66-71.
   doi: 10.1038/nature13007PMID:24476825

Recent Publications

1. Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature , .
   doi: 10.1038/s41586-018-0828-1PMID:30651636
2. Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion. Title, AC, Hong, SJ, Pires, ND, Hasenöhrl, L, Godbersen, S, Stokar-Regenscheit, N, Bartel, DP, Stoffel, M. 2018. Nat Commun 9, 4671.
   doi: 10.1038/s41467-018-07130-zPMID:30405106
3. Predicting microRNA targeting efficacy in Drosophila. Agarwal, V, Subtelny, AO, Thiru, P, Ulitsky, I, Bartel, DP. 2018. Genome Biol. 19, 152.
   doi: 10.1186/s13059-018-1504-3PMID:30286781
4. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Guenther, UP, Weinberg, DE, Zubradt, MM, Tedeschi, FA, Stawicki, BN, Zagore, LL, Brar, GA, Licatalosi, DD, Bartel, DP, Weissman, JS et al.. 2018. Nature 559, 130-134.
   doi: 10.1038/s41586-018-0258-0PMID:29950728
5. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
   doi: 10.1016/j.cell.2018.05.022PMID:29887379
6. New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi. Vyas, VK, Bushkin, GG, Bernstein, DA, Getz, MA, Sewastianik, M, Barrasa, MI, Bartel, DP, Fink, GR. 2018. mSphere 3, .
   doi: 10.1128/mSphere.00154-18PMID:29695624
7. Metazoan MicroRNAs. Bartel, DP. 2018. Cell 173, 20-51.
   doi: 10.1016/j.cell.2018.03.006PMID:29570994
8. A Seed Mismatch Enhances Argonaute2-Catalyzed Cleavage and Partially Rescues Severely Impaired Cleavage Found in Fish. Chen, GR, Sive, H, Bartel, DP. 2017. Mol. Cell 68, 1095-1107.e5.
   doi: 10.1016/j.molcel.2017.11.032PMID:29272705
9. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Rissland, OS, Subtelny, AO, Wang, M, Lugowski, A, Nicholson, B, Laver, JD, Sidhu, SS, Smibert, CA, Lipshitz, HD, Bartel, DP. 2017. Genome Biol. 18, 211.
   doi: 10.1186/s13059-017-1330-zPMID:29089021
10. Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Wu, X, Bartel, DP. 2017. Cell 169, 905-917.e11.
    doi: 10.1016/j.cell.2017.04.036PMID:28525757