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  3. Molecular, Cellular and Circuit Mechanisms that Link Beyond Time
Alcino-Silva-Headshot-300x226.png
The Picower Institute for Learning and Memory
MIT Colloquium on the Brain and Cognition

Molecular, Cellular and Circuit Mechanisms that Link Beyond Time

Speaker(s)
Alcino Silva, PhD
Add to CalendarAmerica/New_YorkMolecular, Cellular and Circuit Mechanisms that Link Beyond Time09/10/2015 8:00 pm09/10/2015 9:30 pm46-3002 Singleton Auditorium
September 10, 2015
8:00 pm - 9:30 pm
Location
46-3002 Singleton Auditorium
Contact
Najat Kessler
Host
Matt Wilson
    Description

    In the last 20 years, there have been significant advances in the molecular, cellular, and systems mechanisms underlying the storage of single memories. Real-world memory, however, involves the integration of multiple memories across time, with one memory affecting how others are processed and stored. Recently, memory allocation studies in our lab indicated that one memory can trigger an increase in excitability that then affect the allocation and strength of a subsequent memory, thus possibly linking the two memories across time. Using a number of techniques including in vivo calcium imaging (with head-mounted fluorescent microscopes in freely behaving mice), the TetTag transgenic system, optogenetics, electrophysiology, 2-photon microscopy and novel behavioral designs, we tested key predictions of the memory allocation hypothesis in hippocampal networks. Our results demonstrate that learning-dependent changes in neuronal excitability can serve to link memories across time.

    For more information about Dr. Silva and his seminar please click here 

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