Presented by the ALANA DOWN SYNDROME CENTER and AGING BRAIN INITIATIVE at the Picower Institute for Learning and Memory, MIT.

About this event

Join us for a joint Alana Down Syndrome Center and Aging Brain Initiative symposium on October 5-6, 2022. The topic this year will be Glial and Neuronal Biology of the Aging Brain.

This event will take place virtually over the course of two days: October 5 and October 6. Talks will begin at 1:00pm ET on October 5 and 9:00am ET on October 6 . The October 6 talks will be followed by a virtual poster session beginning at 12:15pm ET.

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Registration

This event is FREE and OPEN TO THE PUBLIC but registration is required. Please click here to register or enter https://alana-abi.eventbrite.com into your search bar. 

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Location

This will be an entirely virtual event viewable via webcast.

• All registrants will be sent the webcast link via email one week prior to the event (with reminders the day prior and morning of the event). Please keep in mind that emails will be sent to the email address you use to register.

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Agenda

Wednesday, October 5 | Moderator: Ravikiran Raju, Picower Institute, MIT, Boston Children's Hospital

• 1:00-1:10pm: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Lead Investigator, Aging Brain Initiative, Director, Alana Down Syndrome Center
• 1:10-1:40pm: Beth Stevens, Boston Children's Hospital, Harvard Medical School 
• 1:40-2:10pm: Li Gan, Weill Cornell Medical College
• 2:10-2:40pm: Tracy Young-Pearse, Brigham and Women's Hospital, Harvard Medical School , "APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons" 
• 2:40-3:00pm: Break
• 3:00-3:30pm: Elizabeth Head, University of California, Irvine, "Cerebrovascular Pathology as a Function of Age and Alzheimer disease in Down syndrome"
• 3:30-4:00pm: Gilbert Di Paolo, Denali Therapeutics, "Lysosomal Functions of Progranulin and Implications for Treatment of Frontotemporal Dementia" 
• 4:00-4:05pm: Closing Remarks

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Thursday, October 6 | Moderator: TBA

• 9:00-9:10: Opening Remarks
• 9:10-9:40am: Nancy Yuk-Yu Ip, The Hong Kong University of Science and Technology, "Understanding Innate Immunity in Alzheimer's Disease – Insights for the Development of Therapeutics"  
• 9:40-10:10am: Michael Heneka, Luxembourg Centre for Systems Biomedicine (LCSB)
• 10:10-10:40am: Shane Liddelow, NYU, "Reactive Astrocyte Responses to Inflammation and Neurodegeneration"
• 10:40-11:00am: Break
• 11:00-11:30am: Myriam Heiman, Picower Institute, MIT, "Single-cell Dissection of the Human Cerebrovasculature in Health and Disease"
• 11:30am-12:00pm: Adam M. Brickman, Columbia University 
• 12:00-12:05pm: Closing Remarks
• 12:05-12:15pm: Break/Poster Session Set-up
• 12:15-1:15pm: Virtual Poster Session (held on Aimeet)