Date: Wednesday, March 4, 2026
Location: 46-3002 (Singleton Auditorium)

Speaker: Xiao Wang, Ph.D.
Affiliation: Associate Professor, Department of Chemistry, MIT; Core institute member, Broad Institute of MIT and Harvard.

Host: Dr. Guoping Feng

Talk title: Translating 3D molecular atlas to brain function and dysfunction

Abstract: Spatially charting molecular cell types at single-cell resolution across the entire 3D volume of the brain is critical to illustrating the molecular basis of the tissue anatomy and functions. Recent development of spatial transcriptomic methods has enabled scalable profiling of transcriptome-defined spatial cell atlas. Yet, there is still a big gap between spatial cell atlas and brain tissue function. In this presentation, I will introduce a few experimental and computational advances in the mapping of protein synthesis in our lab that further enable multi-modality deep profiling of cell types and states in situ, bridging single-cell molecular profiles with single-cell functional status in intact biological tissues and accelerating gene-to-function discoveries in brain aging and diseases.