This workshop is suitable for postdocs and graduate students who would like to learn the Picower Bioinformatics Online Resources. The workshop will consist of a lecture followed by demo demonstrations to go through the latest NeuVar software tool that annotates brain GWAS variants, human brain chromatin states and transcription factor binding sites for user specified genes/regions/SNPs.
This software generates interactive tables (with sort, search, filter functions) for the overlaps of your query list (with the option to extend up to 20kb around) with the following PILM in-house datasets:
1) Human brain GWAS studies (AD phenotype, different AD neuropathology parameters, Schizophrenia, Smoking, Post-traumatic stress disorder, Bipolar disorder, Alcohol dependence, Subcortical Brain Volume, Education Years, Subjective well-being, Neuroticism and Depressive symptoms). It is expected that new GWAS datasets will be integrated routinely.
2) NIH ROADMAP chromatin states defined by the combination of six histone marks (H3K4m3, H3K4me1, H3K36me3, H3K27me3, H3K9me3 & H3K27ac) in different human brain regions (hippocampus middle, substantia nigra, anterior caudate, cingulate gyrus, interior temporal lobe, angular gyrus & dorsolateral prefrontal cortex) as well as human ES derived neural progenitor cells.
3) NIH ENCODE conserved transcription factor binding sites.

The software also has an interactive graphic interface for visualization. By "clicking" specific rows of the output tables, you can add/delete GWAS points/TF sites on the Genome Annotation Plots.

Please note that the workshop will last for 1 hour, and all the participants are required to bring a laptop with web browser for hands-on practice.