The inaugural symposium of the Alana Down Syndrome Center will feature an informative and engaging afternoon of talks discussing the latest trends in translational research regarding Down syndrome.

Keynote speakers:

• Roger Reeves, McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University
• Joaquin Espinosa, Linda Crnic Institute for Down Syndrome, University of Colorado

Additional Speakers:

• Angelika Amon, MIT, Alana Down Syndrome Center
• Nicole Baumer, Boston Children’s Hospital
• Jeanne Lawrence, University of Massachusetts Medical School
• Brian Skotko, Massachusetts General Hospital
• Eduardo Torres, University of Massachusetts Medical School

Agenda:

1:00 - 1:10pm: Welcome, Li-Huei Tsai, MIT, Co-Director of Alana Down Syndrome Center

Session Chairs: Tim Mullen, Hiruy Meharena

1:10- 1:50pm: Keynote- Joaquin Espinosa, University of Colorado Denver, "The Human Trisome Project: Mechanistic Insights and Therapeutic Opportunities"

1:50-2:15pm: Nicole Baumer, Boston Children’s Hospital, "Optimizing Early Developmental Trajectories in Down syndrome: Research Updates and Opportunities"

2:15-2:40pm: Eduardo Torres, University of Massachusetts Medical School, “Aneuploidy alters the morphology of the nucleus”

2:40-3:05pm: Break

3:05-3:30pm: Brian Skotko, Massachusetts General Hospital, "Down Syndrome Clinic to You (DSC2U): A New Virtual Clinic for All Families"

3:30-3:55pm: Jeanne Lawrence, University of Massachusetts Medical School, “Silencing chromosome 21 in neural cells to advance translational research for Down Syndrome”

3:55-4:20pm: Angelika Amon, MIT, Co-Director of Alana Down Syndrome Center, "General consequences of aneuploidy - implications for Down Syndrome"

4:20-5:00pm: Keynote- Roger Reeves, Johns Hopkins University School of Medicine, “From Mice to Mind, Translational Studies in Down Syndrome”

5:00 - 6:00pm: Reception