Aging Brain Seminar with Kang Shen, PhD, "Understanding Neuronal Cell Biology During Development and Maintenance"
Description
Aging Brain Seminar with Kang Shen, PhD, Stanford University
- Date: Monday, December 8
- Time: 4:00pm
- Location: 46-3310, Picower Seminar Room (In-person only)
- Faculty Host: Li-Huei Tsai
Understanding Neuronal Cell Biology During Development and Maintenance
Neurons are large, complex cells with an extraordinarily long life-span and require specialized mechanisms to accommodate their unique needs for morphogenesis, intracellular trafficking and long term homeostasis. The scarcity of knowledge in neuronal cell biology leads to major gaps in linking genetic variations to behavioral deficits in neurodevelopmental and neurodegenerative disorders. We have established an in vivo system focusing on systematic, mechanistic understanding of specialized neuronal cell biology using this highly polarized, highly arborized C. elegans neuron. In my presentation, I will present our recent and largely unpublished results on how HDAC inhibition resolves ER stress and endosomal trafficking stress in C. elegans and vertebrate neurons.
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About the Aging Brain Initiative
This interdisciplinary research effort pulls together faculty expertise, knowledge, and technical resources from across MIT to solve the mysteries of the aging brain. It spans neuroscience, fundamental biology and genetics, investigative medicine, engineering and computer science, economics, chemistry, urban planning, and artificial intelligence to enable a comprehensive systems approach. What's the ultimate mission? To deliver the basic research that makes possible new tools to address the challenges of brain aging and create a better future for millions.