Mechanisms of neurogenesis and neural repair
We study the mechanisms of neurogenesis in order to implement them for neuronal repair. I will present unpublished work about novel molecular mechanisms important for neurogenesis in the developing murine cerebral cortex and will then turn to using these for direct neuronal reprogramming after traumatic injury of the adult murine cerebral cortex in vivo. I will discuss different viral vector approaches and up-date on a recent breakthrough in direct glia-to-neuron reprogramming achieving high efficiency and mature neuronal subtypes sending out long range projections. I will close by discussing the integration of replaced neurons into the circuitry of the adult murine cerebral cortex, that normally does not integrate new neurons at adult stages and present unpublished data about the mechanisms regulating this integration. Taken together, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair.